What is postmortem drug redistribution?
Postmortem drug redistribution refers to the processes by which the movement of drugs and other chemical poisons between tissues, organs, and body fluids takes place after death.
What does post-mortem toxicology show?
Toxicology tests performed for autopsies are called forensic or post-mortem toxicology tests. These tests determine if and what kind of drugs were in a person’s system. Experts also measure the amount of drugs and look to see if the concentration is of a lethal dosage.
What is PMR in forensic science?
Background. Postmortem redistribution (PMR) refers to the changes that may occur in drug concentrations after death. Consequently, postmortem concentrations in blood may not always replicate the antemortem drug levels. Conversely, drugs with a L/P ratio greater than 20 to 30 (L/kg) have propensity for substantial PMR.
Which organ is used for post-mortem toxicology?
The liver is a primary solid tissue for use in post-mortem toxicology because it is where the body metabolizes most drugs and toxicants. Many drugs become concentrated in the liver and can be found even when there are no levels in the blood. In this latter situation, interpretation of findings is complex.
How long do drugs stay in the body after death?
Most drugs of abuse stay in the body for at least a few days after the last use and are traceable with urine tests. Opioids like heroin and oxycodone are detectable for between 1 and 3 days after last use.
Why is post mortem redistribution important?
Postmortem redistribution (PMR) refers to the changes that occur in drug concentrations after death. Correlation with laboratory data and any available antemortem or perimortem clinical information is necessary to render an appropriate opinion on the cause of death.
How long do post mortem toxicology results take?
Popular “crime scene investigation” television programs are able to complete toxicology reports in a very short (and unrealistic) time frame. However, in reality, while an autopsy is usually completed within a day or two after a death, the final results of the toxicology report may take four to six weeks or longer.
What happens if no cause of death is found?
If no cause of death is discovered when the report is written, it is usually stated to be ‘unascertained’ or ‘unascertainable’. For the latter, an inquest may be held and further evidence may be produced that does lead, with the autopsy findings, to a satisfactory cause of death.
What is post mortem blood?
Postmortem redistribution (PMR) refers to the changes that occur in drug concentrations after death. It involves the redistribution of drugs into blood from solid organs such as the lungs, liver, and myocardium.
What is workplace drug testing primarily concerned with?
Initial and confirmatory testing are also instituted. Workplace drug testing is primarily limited to drugs with the potential for abuse, including some prescription drugs, and alcohol.
Why is post-mortem redistribution important?