What is spindle cell melanoma?
Spindle cell melanoma (SCM) is a rare subtype of malignant melanoma composed of spindled neoplastic cells arranged in sheets and fascicles (1). The diagnosis of SCM is challenging, as SCM may occur anywhere on the body and frequently mimics amelanotic lesions, including scarring and inflammation (2–4).
What does spindle cell melanoma look like?
Features of spindle cell melanoma under microscopy include: An abundance of spindle-shaped tumour cells (> 90% of a tumour) Uniform, wavy, and slender nuclei, with variable size and shapes (pleomorphism) and variable nuclear atypia (abnormal appearance of cell nuclei)
What is the most aggressive skin cancer?
Melanoma has its beginnings in melanocytes, the skin cells that produce the dark, protective pigment called melanin which makes the skin tan. Melanoma is the most deadly of all the skin cancers and affects over 44,000 Americans each year.
How long does it take for melanoma to spread to organs?
It can become life-threatening in as little as six weeks and, if untreated, it can spread to other parts of the body.
Where does melanoma spread first?
Normally, the first place a melanoma tumor metastasizes to is the lymph nodes, by literally draining melanoma cells into the lymphatic fluid, which carries the melanoma cells through the lymphatic channels to the nearest lymph node basin.
What is Spitzoid melanoma?
Spitzoid melanoma is a type of skin cancer. It begins when the melanocytes in the skin grow out of control and form tumors. Melanocytes are the cells responsible for making melanin, the pigment that determines the color of the skin.
Which are the worst cancers?
List of cancer mortality rates in the United States
|Type||Mortality rates for all cancers in 2019|
|Liver cancer and bile duct cancer||90|
What are the signs of Superficial Spreading Melanoma?
Learn more about melanoma risk factors . The main sign of superficial spreading melanoma is an unusual-looking spot that changes in size or appearance. Other signs include spots with uneven borders or color variations in the same spot. Learn more about how to identify melanoma .
What does a large asymmetrical melanoma look like?
A large, asymmetrical melanoma with an uneven color and irregular border. A large, asymmetrical melanoma that is more than 10 millimeters (about 1/2 inch) wide. A melanoma with uneven color, an irregular border, and a scaly or flaky area. A melanoma with an irregular border.
What kind of cells are involved in melanoma?
It begins in skin cells called melanocytes. Melanocytes produce melanin, the substance that gives your skin color. Only about 1 percent of skin cancers are melanomas.
What are the features of melanoma in the spinal cord?
MRI of spinal cord melanoma shows characteristic features such as high signal intensity on T1-weighted images and equal or low signal intensity on T2-weighted images, [ 6] due to the paramagnetic properties of melanin or the hemorrhagic elements in the tumor. [ 6]