What is the role of Rab5 in endocytosis?
Early endosome marker Rab5 GTPase, a key member of the Rab family, plays a crucial role in endocytosis and membrane transport. The activated-state Rab5 recruits its effectors and regulates the internalization and trafficking of membrane receptors by regulating vesicle fusion and receptor sorting in the early endosomes.
How is EGF-dependent cell proliferation enhanced in endocytosis?
EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up-regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation.
How does receptor mediated endocytosis ( RME ) work?
Receptor-mediated endocytosis ( RME ), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane ( invagination ).
How does Rab5 regulate the internalization of receptors?
The activated-state Rab5 recruits its effectors and regulates the internalization and trafficking of membrane receptors by regulating vesicle fusion and receptor sorting in the early endosomes.
What is the role of Rab5 in membrane receptor trafficking?
In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development.
How are Rab proteins similar to Ras proteins?
Rab proteins are similar to Ras and other GTP-bound proteins in their structures. They are composed of approximately 200 amino acids, and contain five highly conserved regions necessary for binding GTP and hydrolysis. Rab proteins are present in monomeric forms, and the amino acid sequence similarity of Rab family members ranges from 35% to 80% [ 2