How effective is Alectinib?
The recent updated results from the ALEX clinical trial showed a higher 5-year overall survival rate for alectinib of 62.5% compared to 45.5% with crizotinib. Bottom line: Alectinib is an effective medicine used to treat metastasized anaplastic lymphoma kinase positive non-small cell lung cancer.
Where is Alectinib made?
Alecensa (RG7853/AF-802/RO5424802/CH5424802) is a highly selective, CNS active, oral medicine created at Chugai Kamakura Research Laboratories and is being developed for people with NSCLC whose tumours are identified as ALK-positive.
How much does Alectinib cost?
The monthly cost of Alecensa will be approximately $12,500.
How is Alectinib administered?
The recommended dose of ALECENSA is 600 mg orally twice daily [see Clinical Pharmacology (12.3)]. Administer ALECENSA until disease progression or unacceptable toxicity.
Does alectinib cause weight gain?
The following additional clinically significant adverse drug reactions were observed in patients treated with ALECENSA: weight gain (9.9%), photosensitivity reaction (5.3%), stomatitis (3.3%), interstitial lung disease (1.3%), and drug-induced liver injury (1.3%).
How long can you take alectinib?
by Drugs.com In the clinical trial ALEX: NCT02075840, the length of time Alecensa was taken ranged from months to over a year, with the median length of time being 18.6 months. Alecensa treatment usually continues until there is disease progression or the patient has unacceptable side effects.
What is another name for Alectinib?
Alectinib is the generic name for the trade name drug Alecensa®. In some cases, health care professionals may use the trade name Alecensa® when referring to the generic drug name alectinib. Drug Type: Alectinib is an anti-cancer (“antineoplastic”) targeted therapy.
When should I take Alectinib?
Alectinib is used to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to other parts of the body. Alectinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply.
What is another name for alectinib?
What are the side effects of Alecensa?
The most common side effects of ALECENSA include:
- Tiredness.
- Constipation.
- Swelling in your hands, feet, ankles, face, and eyelids.
- Muscle pain, tenderness, and weakness (myalgia)
- Low red blood cell count.
What kind of lung cancer does Alecensa treat?
Important Safety Information & Indication. ALECENSA is a prescription medicine used to treat people with non-small cell lung cancer that has spread to other parts of the body (mNSCLC) and is caused by an abnormal anaplastic lymphoma kinase (ALK) gene.
Who is eligible to take Alecensa for NSCLC?
ALECENSA is approved to treat people with non-small cell lung cancer that has spread to other parts of the body and whose type of NSCLC is caused by an abnormal anaplastic lymphoma kinase gene (ALK+ mNSCLC). To be eligible to take ALECENSA, a diagnostic test must confirm that your NSCLC is caused by abnormal ALK proteins.
What are the side effects of taking Alecensa?
ALECENSA may cause severe or life-threatening swelling (inflammation) of the lungs during treatment. Symptoms may be similar to those symptoms from lung cancer. Tell your doctor right away if you have any new or worsening symptoms, including: Kidney problems. ALECENSA may cause severe or life-threatening kidney problems.
When was alectinib approved for the treatment of lung cancer?
Alectinib was approved in Japan in July 2014[5]for the treatment of ALK fusion-gene positive, unresectable, advanced or recurrent non-small-cell lung cancer (NSCLC). [4]