Are there any antibodies that target DHX9 in mice?
17721-1-AP targets DHX9 in WB, RIP, IP, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
How does DHX9 play a role in DNA replication?
Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed: 12711669 ). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed: 24990949 ).
How is DHX9 related to the DEAH family?
DHX9 a member of the DEAH family of proteins, which possess a double-stranded RNA-binding domain (dsRBD) and a helicase domain [PMID:20569003]. It unwinds double-stranded DNA and RNA in a 3′ to 5′ direction. Alteration of secondary structure of DHX9 may subsequently influence interactions with proteins or other nucleic acids.
How does DHX9 interact with the PARP1 protein?
A top candidate DHX9 helicase promotes R-loop suppression and transcriptional termination. DHX9 interacts with PARP1, and both proteins prevent R-loop-associated DNA damage. DHX9 and other interactome helicases are overexpressed in cancer, linking R-loop-mediated DNA damage and disease.
What is the function of the helicase DHX9?
Helicase proteins have a diverse range of cellular functions that stem from their ability to resolve and remodel DNA and RNA structures. DExH-Box helicase 9 (DHX9), also known as RNA helicase A (RHA), belongs to the DExD/H-Box superfamily II of helicases [ 1 ].
What kind of RNA binding domain does DHX9 have?
DHX9 a member of the DEAH family of proteins, which possess a double-stranded RNA-binding domain (dsRBD) and a helicase domain [PMID:20569003]. It unwinds double-stranded DNA and RNA in a 3′ to 5′ direction.