What does concentric remodeling mean?
Concentric remodeling is the late stage response to LV hypertrophy; caused by either chronic pressure, volume overload or a MI (which is commonly associated with CAD, but can be due to longstanding hypertension, especially untreated).
What is the difference between concentric and eccentric cardiac remodeling?
Concentric hypertrophy is associated with increased left ventricular wall thickness whereas eccentric hypertrophy is characterized by dilatation of the left ventricular chamber; however, there occurs a general increase in the overall size of cardiomyocytes under both conditions.
Can concentric remodeling be reversed?
Cardiac remodeling comprises changes in ventricular volume as well as the thickness and shape of the myocardial wall. With optimized treatment, such remodeling can be reversed, causing gradual improvement in cardiac function and consequently improved prognosis.
What is the meaning of concentric LVH?
Concentric left ventricular hypertrophy is an abnormal increase in left ventricular myocardial mass caused by chronically increased workload on the heart, most commonly resulting from pressure overload-induced by arteriolar vasoconstriction as occurs in, chronic hypertension or aortic stenosis.
Is concentric remodeling normal?
LV concentric remodelling secondary to hypertension is a subtle and early change in cardiac geometry characterised by increased LV relative wall thickness (RWT) with normal overall muscle mass, which seems to be associated with a greater cardiovascular risk than is the normal LV geometry pattern.
Is concentric remodeling bad?
Conclusions: Concentric remodeling of the left ventricle, defined by the thickness of the septum or posterior wall divided by the left ventricular radius at end-diastole > or = 0.45, is an important and independent predictor of increased cardiovascular risk in hypertensive patients with normal left ventricular mass on …
What does concentric and eccentric mean?
In a concentric contraction, the muscle tension rises to meet the resistance then remains stable as the muscle shortens. During eccentric contraction, the muscle lengthens as the resistance becomes greater than the force the muscle is producing.
Why is heart remodeling bad?
Cardiac remodeling is associated with the development and progression of ventricular dysfunction, arrhythmias and poor prognosis. After MI, may predispose to ventricular rupture and aneurysm formation. Despite therapeutic advances, mortality rates related to cardiac remodeling/dysfunction remain high.
Is concentric LVH serious?
Left ventricular hypertrophy occurs commonly in people with a history of high uncontrolled blood pressure. Hence, having blood pressure in control is one of the main ways to avoid LVH. LVH leads to a higher risk of congestive heart failure and irregular heart rhythms, which are life-threatening heart conditions.
What causes concentric left ventricular Remodelling?
Under pressure overload, remodeling is primarily concentric because of the addition of myocyte sarcomeres in parallel. Therefore, LV wall thickness increases to a greater extent than the volume of the LV cavity; as a result, the ratio of LV mass to end-diastolic volume (M/V ratio) increases.
What is harder concentric or eccentric?
It is well acknowledged that muscles that are elongated while activated (i.e., eccentric muscle action) are stronger and require less energy (per unit of force) than muscles that are shortening (i.e., concentric contraction) or that remain at a constant length (i.e., isometric contraction).
How is the definition of concentric remodeling determined?
Baseline echocardiography and 24-h noninvasive ambulatory blood pressure monitoring were performed in all patients at the time of initial diagnostic evaluation. Concentric remodeling was defined by the thickness of the septum or posterior wall divided by the left ventricular radius at end-diastole ≥0.45.
What causes concentric remodeling in LV hypertrophy?
Concentric remodeling is the late stage response to LV hypertrophy; caused by either chronic pressure, volume overload or a MI (which is commonly associated with CAD, but can be due to longstanding hypertension, especially untreated).
What are the risks of concentric remodeling of the left ventricle?
An echocardiographic pattern of concentric remodeling of the left ventricle has been associated with clinical features of increased cardiovascular risk, but the independent prognostic value of this finding in hypertensive patients with normal left ventricular mass has not been established.
How many patients are treated with LV concentric remodeling?
We studied 1088 mild hypertensive patients (clinic BP 140 to 159 mm Hg systolic or 90 to 99 mm Hg diastolic), comprising 751 patients with normal LV geometry and 337 with LV concentric remodeling (defined later here). This sample of mild hypertensive patients was taken from a larger population of 1479 untreated patients with mild hypertension.