What are allogeneic donors?

Allogeneic (A-loh-jeh-NAY-ik) means the stem cells are taken from a donor (you) and given to another person. Peripheral blood is the blood that circulates in your blood vessels. After they’re harvested, your stem cells will be given to a patient in a peripheral blood stem cell transplant.

What is allogeneic bone marrow transplant?

Listen to pronunciation. (A-loh-jeh-NAY-ik bone MAYR-oh TRANZ-plant) A procedure in which a patient receives healthy stem cells (blood-forming cells) to replace their own stem cells that have been destroyed by treatment with radiation or high doses of chemotherapy.

What is the difference between allogeneic and autologous?

Autologous: Auto means self. The stem cells in autologous transplants come from the same person who will get the transplant, so the patient is their own donor. Allogeneic: Allo means other. The stem cells in allogeneic transplants are from a person other than the patient, either a matched related or unrelated donor.

What are allogeneic cells?

In an allogeneic transplant, stem cells are collected from a matching donor and transplanted into the patient to suppress the disease and restore the patient’s immune system. An allogeneic stem cell transplant is different from an autologous stem cell transplant, which uses stem cells from the patient’s own body.

What is the difference between allogeneic and syngeneic?

A syngeneic graft is known as an isograft. Related terms include: autogeneic, referring to autotransplantation, also termed autograft, (from one part of the body to another in the same person) allogeneic, referring to allotransplantation or an allograft (from other individual of same species).

Why is allogeneic better?

Allogeneic transplantation has the advantage that the graft is free of contaminating tumor cells. The graft also includes donor-derived immunocompetent cells which may produce an immune graft-versus-malignancy effect.

Can you have 2 stem cell transplants?

In some cases, the same donor might be used as your first transplant, but the transplant will be done with different chemotherapy drugs. Unfortunately, a second transplant isn’t a suitable option for everyone. Clinical trials are a type of medical research study – a way of thoroughly testing new types of treatments.

What does engraftment mean?

Engraftment is when the blood-forming cells you received on transplant day start to grow and make healthy blood cells. It’s an important milestone in your transplant recovery.

Are taken from a donor of same species?

Allotransplant (allo- meaning “other” in Greek) is the transplantation of cells, tissues, or organs to a recipient from a genetically non-identical donor of the same species. The transplant is called an allograft, allogeneic transplant, or homograft. Most human tissue and organ transplants are allografts.

What is allogeneic product?

Allogeneic therapies are manufactured in large batches from unrelated donor tissues (such as bone marrow) whereas autologous therapies are manufactured as a single lot from the patient being treated. For some autologous therapies, the cells from the patient are processed on site at the clinic or hospital.

What is Xenogeneic transplant?

Removing the barriers to xenogeneic (cross-species) transplantation could open the way to organ banks with an unlimited supply of replacement cells and organs. Xenogeneic tissue has advantages and disadvantages compared to human tissue—some obvious, some less obvious, some potential.

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