How is rosuvastatin metabolized?
Rosuvastatin is metabolized mainly by CYP2C9 and not extensively metabolized; approximately 10% is recovered as metabolite N-desmethyl rosuvastatin. It is excreted in feces (90%) primarily and the elimination half-life is approximately 19 hours.
Where is rosuvastatin absorbed?
Pharmacology/Pharmacokinetics/Stability: Following oral administration, rosuvastatin is absorbed rapidly from the gut, reaching peak plasma drug levels in three to five hours. The average half-life (time needed for half the active drug to be eliminated from the body) is 19 hours.
How does rosuvastatin work in the body?
Rosuvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
Is 40 mg of rosuvastatin a lot?
If you have very high cholesterol, you may be prescribed a higher dose of 40mg a day by a specialist. This dosage is not suitable for everyone. Ask your doctor or pharmacist for advice if you’re unsure how much to take. Do not reduce your dose without talking to your doctor first.
When is the best time to take rosuvastatin?
Studies show that some of the newer statins can be just as effective when taken in the morning. HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins. They have half-lives of at least 14 hours. Extended-release fluvastatin, or Lescol XL, can be taken at any time of day.
What drugs should not be taken with rosuvastatin?
Serious interactions of rosuvastatin include:
- atazanavir.
- clarithromycin.
- colchicine.
- cyclosporine.
- eltrombopag.
- fenofibrate.
- fenofibrate micronized.
- fenofibric acid.
Can I take vitamin D with rosuvastatin?
Interactions between your drugs No interactions were found between rosuvastatin and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Is 40 mg of rosuvastatin safe?
The overall pattern and incidence of AEs and abnormal laboratory values were consistent with the published safety profile of rosuvastatin and higher doses of other statins. In conclusion, long-term treatment with rosuvastatin 40 mg is safe and effective in patients with severe hypercholesterolemia.
Does rosuvastatin cause sleep problems?
The top-selling statins are atorvastatin (Lipitor), lovastatin (Mevacor), rosuvastatin (Crestor) and simvastatin (Zocor). How they can cause insomnia: The most common side effect of all types of statins is muscle pain, which can keep people who take them awake at night and unable to rest.
What’s the maximum dosage of rosuvastatin you can take?
Dosage adjustment for rosuvastatin with concomitant medications: Oral: Gemfibrozil: Avoid concurrent use; if unable to avoid concurrent use, initiate rosuvastatin at 5 mg once daily (maximum: 10 mg/day) Atazanavir/ritonavir, lopinavir/ritonavir, or simeprevir: Initiate rosuvastatin at 5 mg once daily (maximum: 10 mg/day).
How is rosuvastatin metabolized in the body?
Rosuvastatin is 88% bound to plasma proteins, mostly albumin. This binding is reversible and independent of plasma concentrations 1 Metabolism: Rosuvastatin is not extensively metabolized; approximately 10% of a radiolabeled dose is recovered as metabolite. The major metabolite is N-desmethyl rosuvastatin,…
What’s the generic name for rosuvastatin ezallor?
Rosuvastatin Generic Name: rosuvastatin (roe SOO va sta tin) Brand Name: Crestor, Ezallor Sprinkle Dosage Forms: oral capsule (10 mg; 20 mg; 40 mg; 5 mg); oral tablet (10 mg; 20 mg; 40 mg; 5 mg)
How does Crestor affect the AUC of rosuvastatin?
Both C max and AUC increased in approximate proportion to CRESTOR ® (rosuvastatin calcium) dose. The absolute bioavailability of rosuvastatin is approximately 20%. Administration of CRESTOR with food did not affect the AUC of rosuvastatin. The AUC of rosuvastatin does not differ following evening or morning drug administration 1