What is iron chelating activity?
Iron chelators mobilize tissue iron by forming soluble, stable complexes that are then excreted in the feces and/or urine. Chelation therapy reduces iron-related complications and thereby improves quality of life and overall survival (Shinar and Rachmilewitz, 1990; Hebbel et al., 1990).
Does iron act as an antioxidant?
It can be concluded from the study that all the iron chelators have antioxidant and free radical scavenging activities.
What is metal chelating ability?
Metal chelation enhances the antioxidant properties of Curcumin. • Curcumin acts as an active metal chelating agent as well as an antioxidant. • Curcumin can be used in chelation therapy for the cure of metal induced-neurodegenerative diseases.
What is chelation value?
The total chelation value is determined by titrating with a solution of calcium salt in the presence of oxalate ion at a pH of 11.0 or slightly higher.
What do chelating agents do?
OVERVIEW. Chelating agents are used to reduce blood and tissue levels of injurious heavy metals. Chelating agents are generally classified based upon the target heavy metal – iron, copper, mercury and lead being the major targets.
Are chelating agents antioxidants?
Chelating agents which chelate metallic ions such as copper and iron (citric acid, phytic acid) Of these antioxidants, ascorbic acid and chelating agents are able to enhance the antioxidant action of tocopherols or phenolic compounds, and are therefore called synergists.
What is chelation effect?
The chelate effect is the enhanced affinity of a chelating ligand for a metal ion compared to its monodentate ligand counterpart(s). This term comes from the Greek chelos, meaning “crab”. Tridentate ligands, which bind through three donors, can bind even more tightly than bidentate, and so on.
What is ferrous ion chelating activity ( FICA )?
R. M. Patel, “Ferrous ion chelating activity (FICA)- a comparative antioxidant activity evaluation of extracts of eleven naturally growing plants of Gujarat, India,” International Journal of Scientific Research, vol. 2, no. 8, 2013. View at: Google Scholar ].
How are ferrozine and ferrous iron complexes related?
Ferrozine can quantitatively form complexes with ferrous iron yielding a red colour. However, in the presence of chelating agents, there is disruption of the formation of the complex which leads to a decrease in the red colour. Measurement of colour reduction gives an estimation of the binding ability of the coexisting chelator.
How is the binding ability of iron chelators determined?
Iron (II) binding ability of the chelators was determined according to the method of Dinis et al. [13] except that ferrous sulphate was substituted for ferrous chloride. Ferrozine can quantitatively form complexes with ferrous iron yielding a red colour.
What is the antioxidant activity of iron chelators?
In this study, the antioxidant activity of the iron chelators: caffeic acid (CA), 2,3-dihydroxybenzoic acid (DHBA), desferroxamine B (FOB) and benzohydroxamic acid (BHA) were determined using five different in vitro antioxidant assays.