What does interferon alfa-2a do?
INTERFERON ALFA-2a (in ter FEER on AL fa 2 a) (Roferon-A) helps the immune system fight viral infections such as chronic hepatitis C, and certain cancers like Philadelphia chromosome positive chronic myelogenous leukemia, and hairy cell leukemia.
What formulations of interferon alfa are available?
il, intralesional; im, intramuscular; iv, intravenous; sc, subcutaneous. Pegylated interferon alfa-2b is a covalent conjugate of human interferon alfa-2b with monomethoxy-polyethylene glycol (PEG).
Is peginterferon the same as interferon?
Overview. Pegylated interferon, usually called peginterferon, is a chemically modified form of the standard interferon that treats hepatitis C and rarely hepatitis B. The difference between interferon and peginterferon is the PEG, which stands for a molecule called polyethylene glycol.
Is interferon toxic?
Preliminary data show evidence for some growth retardation in patients receiving long-term interferon therapy. Laboratory evidence of toxicity in the form of decreased WBC, RBC, and platelet counts occurred in five patients, and increased liver enzymes occurred in 16 patients.
What type of drug is interferon?
Interferon alfa belongs to the category of therapies called biologic response modifiers (BRM), also called immunotherapy. This is a type of treatment that mobilizes the body’s immune system to fight cancer.
Is interferon considered chemotherapy?
Interferon-alfa2b is different than a chemotherapy drug; it is actually a natural part of your body’s immune system. It is known as a cytokine, which are chemicals normally secreted by cells called leukocytes in response to a virus, bacteria, or other foreign intruders.
What kind of protein is interferon alfa-2a?
Roferon-A (Interferon alfa-2a, recombinant) is a sterile protein product for use by injection. Roferon-A (interferon alfa-2a, recombinant) is manufactured by recombinant DNA technologythat employs a genetically engineered Escherichia coli bacteriumcontaining DNA that codes for the human protein.
What kind of injection is intron alfa 2b?
INTRON ® A (Interferon alfa-2b) for intramuscular, subcutaneous, intralesional, or intravenous Injection is a purified sterile recombinant interferon product. INTRON A recombinant for Injection has been classified as an alpha interferon and is a water-soluble protein with a molecular weight of 19,271 daltons produced by recombinant DNA techniques.
Which is the best recombinant human interferon alfa?
In the transformation of cells of the recipient strain E. coli BL21 recombinant plasmid DNA pSX50 the resulting strain E. coli SX50 – producer of recombinant leukocyte alpha-2b interferon man with a productivity of up to 0.9-1.0 g of alpha-2b interferon with 1 l of culture medium.
When to use interferon alfa-2a multidose solution?
Store interferon alfa-2a in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius). Do not allow interferon alfa-2a to freeze. The Roferon-A multidose vials of injectable solution should be used within 30 days after the first dose is taken from the vial.